JavaScript is a versatile programming language primarily used for client-side scripting on web browsers. It allows developers to create dynamic content, control multimedia, animate images, and much more. Node.js, on the other hand, enables JavaScript to be used for server-side scripting, allowing developers to build scalable network applications. In this comprehensive article, we'll explore the core differences between JavaScript and Node.js, their use cases, and how they can be effectively utilized in modern web development. We will also look into the advantages of using Node.js for backend development and how it complements JavaScript's capabilities for frontend tasks. By the end of this article, readers will have a clear understanding of when to use each and how they can work together to create robust applications.